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POSTERS: Molecular/Cellular Plant‐Microbe Interactions II

P-366 - Targeting Histidine Kinases : A Novel Mechanism of Resveratrol Oligomers in Plant Protection

Tuesday, August 5, 2025
10:15 AM - 11:00 AM HST
Location: Exhibit Hall 3

    Presenting Author(s)

  • JK

    Jieun Kang

    Postdoctoral Researcher
    Michigan State University
    East Lansing, MI, USA

    • Author(s)

  • NY

    Nayeon Yoo

    Korea University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • EC

    Eui-Hwan Chung

    Korea University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • AS

    Aleksandra Skirycz

    Michigan State University
    East Lansing, Michigan, United States

Abstract Text: Resveratrol and its derivatives are widely studied for their diverse biological activities, including antioxidant, anticancer, anti-inflammatory, antiviral, and antimicrobial properties. In our previous studies, we discovered that certain resveratrol oligomers exhibit antivirulence activity against plant pathogens while also enhancing plant immunity in Arabidopsis and tobacco. From a crop protection perspective, this is a significant finding, as these compounds possess dual functionalities: suppressing bacterial pathogenesis and strengthening plant defense mechanisms against infections.

To investigate the mode of action underlying these phenotypes, transcriptome analysis suggested that resveratrol oligomers may interact with bacterial histidine kinases, as their transcriptional levels were significantly upregulated in the presence of the compound. Additionally, their associated response regulator genes were also upregulated. To validate this hypothesis, we employed in vitro binding assays, including Microscale Thermophoresis (MST) and nano-differential scanning fluorimetry (nanoDSF), to assess direct interactions between bacterial histidine kinases and resveratrol oligomers.

Our findings provide insight into how resveratrol and its derivatives exert antivirulnece effects in pathogenic bacteria. Furthermore, these results suggest that their plant immunity-enhancing effects may stem from direct interactions with eukaryotic histidine kinases, which we aim to explore further.